Publications

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Currently displaying 161 - 180 of 272 publications

Author(s)

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Journal Name

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Min

Max

Bioorthogonal Decaging Reactions for Targeted Drug Activation

S Davies, BJ Stenton, GJL Bernardes

Chimia (Aarau)

(2018)

771

(doi: 10.2533/chimia.2018.771)

Modular pore-forming immunotoxins with caged cytotoxicity tailored by directed evolution

NL Mutter, M Soskine, G Huang, IS Albuquerque, GJL Bernardes, G Maglia

ACS Chem Biol

(2018)

3153

(doi: 10.1021/acschembio.8b00720)

Cisplatin-Triggered Bioorthogonal Decaging of Amide Bonds for Targeted-Drug Activation in vivo

B Stenton, B Oliveira, J Conde, M Negrão, M Godinho Ferreira, R Fior, G Bernardes

(2018)

(doi: 10.26434/chemrxiv.7327904.v1)

Posttranslational chemical mutagenesis: to reveal the role of non-catalytic cysteine residues in pathogenic bacterial phosphatases

JB Bertoldo, H Terenzi, S Hüttelmaier, GJL Bernardes

Biochemistry

(2018)

6144

(doi: 10.1021/acs.biochem.8b00639)

Discovery of 2,4-dimethoxypyridines as novel autophagy inhibitors

L Robke, T Rodrigues, P Schröder, DJ Foley, GJL Bernardes, L Laraia, H Waldmann

Tetrahedron

(2018)

4531

(doi: 10.1016/j.tet.2018.07.021)

Synthesis and Biological Evaluation of Homogeneous Thiol-Linked NHC*-Au-Albumin and -Trastuzumab Bioconjugates.

MJ Matos, C Labão-Almeida, C Sayers, O Dada, M Tacke, GJL Bernardes

Chemistry - A European Journal

(2018)

12250

(doi: 10.1002/chem.201800872)

Machine intelligence decrypts β-lapachone as an allosteric 5-lipoxygenase inhibitor.

T Rodrigues, M Werner, J Roth, EHG da Cruz, MC Marques, P Akkapeddi, SA Lobo, A Koeberle, F Corzana, EN da Silva Júnior, O Werz, GJL Bernardes

Chemical Science

(2018)

6899

(doi: 10.1039/c8sc02634c)

Site-selective installation of an electrophilic handle on proteins for bioconjugation

B Lee, S Sun, E Jiménez-Moreno, AA Neves, GJL Bernardes

Bioorganic & Medicinal Chemistry

(2018)

3060

(doi: 10.1016/j.bmc.2018.02.028)

Sustainable Polysulfides for Oil Spill Remediation: Repurposing Industrial Waste for Environmental Benefit

MJH Worthington, CJ Shearer, LJ Esdaile, JA Campbell, CT Gibson, SK Legg, Y Yin, NA Lundquist, JR Gascooke, IS Albuquerque, JG Shapter, GG Andersson, DA Lewis, GJL Bernardes, JM Chalker

Advanced Sustainable Systems

(2018)

1800024

(doi: 10.1002/adsu.201800024)

Artificial Intelligence Recognizes β-Lapachone as an Allosteric 5- Lipoxygenase Inhibitor

G Bernardes, T Rodrigues, M Werner, J Roth, EHG da Cruz, MC Marques, SA Lobo, A Koeberle, F Corzana, E N. da Silva Júnior, O Werz

(2018)

(doi: 10.26434/chemrxiv.6026795.v1)

Chemo- and Regioselective Lysine Modification on Native Proteins

MJ Matos, BL Oliveira, N Martínez-Sáez, A Guerreiro, PMSD Cal, J Bertoldo, M Maneiro, E Perkins, J Howard, MJ Deery, JM Chalker, F Corzana, G Jiménez-Osés, GJL Bernardes

Journal of the American Chemical Society

(2018)

140

4004

(doi: 10.1021/jacs.7b12874)

Antikörpergerichtete Therapien: Quo vadis?

T Rodrigues, GJL Bernardes

Angewandte Chemie

(2018)

130

2050

(doi: 10.1002/ange.201712185)

A Fluorogenic Probe for Cell Surface Phosphatidylserine Using an Intramolecular Indicator Displacement Sensing Mechanism

VE Zwicker, BL Oliveira, JH Yeo, ST Fraser, GJL Bernardes, EJ New, KA Jolliffe

Angewandte Chemie (International ed. in English)

(2018)

3087

(doi: 10.1002/anie.201812489)

Development of Antibody‐Directed Therapies: Quo Vadis?

T Rodrigues, GJL Bernardes

Angewandte Chemie (International ed. in English)

(2018)

2032

(doi: 10.1002/anie.201712185)

A silicon-labelled amino acid suitable for late-stage fluorination and unexpected oxidative cleavage reactions in the preparation of a key intermediate in the Strecker synthesis

KR Scroggie, LJ Alcock, MJ Matos, GJL Bernardes, MV Perkins, JM Chalker

Peptide Science

(2018)

110

e24069

(doi: 10.1002/pep2.24069)

A thioether-directed palladium-cleavable linker for targeted bioorthogonal drug decaging.

BJ Stenton, BL Oliveira, MJ Matos, L Sinatra, GJL Bernardes

Chemical Science

(2018)

4185

(doi: 10.1039/c8sc00256h)

The Use of Fluoroproline in MUC1 Antigen Enables Efficient Detection of Antibodies in Patients with Prostate Cancer.

VJ Somovilla, IA Bermejo, IS Albuquerque, N Martínez-Sáez, J Castro-López, F García-Martín, I Compañón, H Hinou, S Nishimura, J Jiménez-Barbero, JL Asensio, A Avenoza, JH Busto,, R Hurtado-Guerrero, JM Peregrina, GJ Lopes Bernardes, F Corzana1

J Am Chem Soc

(2017)

139

18255

(doi: 10.1021/jacs.7b09447)

Chemoselective Installation of Amine Bonds on Proteins through Aza-Michael Ligation.

AM Freedy, MJ Matos, O Boutureira, F Corzana, A Guerreiro, P Akkapeddi, VJ Somovilla, T Rodrigues, K Nicholls, B Xie, G Jiménez-Osés, KM Brindle, AA Neves, GJL Bernardes

J Am Chem Soc

(2017)

139

18365

(doi: 10.1021/jacs.7b10702)

Precise Probing of Residue Roles by Post-Translational β,γ-C,N Aza-Michael Mutagenesis in Enzyme Active Sites

J Dadová, K-J Wu, PG Isenegger, JC Errey, GJL Bernardes, JM Chalker, L Raich, C Rovira, BG Davis

ACS Cent Sci

(2017)

1168

(doi: 10.1021/acscentsci.7b00341)

Oxetane Grafts Installed Site‐Selectively on Native Disulfides to Enhance Protein Stability and Activity In Vivo

N Martínez-Sáez, S Sun, D Oldrini, P Sormanni, O Boutureira, F Carboni, I Compañón, MJ Deery, M Vendruscolo, F Corzana, R Adamo, GJ Lopes Bernardes

Angewandte Chemie (International ed. in English)

(2017)

14963

(doi: 10.1002/anie.201708847)

Interested in joining the GBernardesLab?

We are always looking for enthusiastic and bright researchers to join the lab. If you are interested in joining the group, please contact Gonçalo directly at gb453@cam.ac.uk.

All applications should include a cover letter that highlights your research interests, a full CV, and the names and addresses of two referees.

Funded PhD and Postdoctoral positions will be advertised when available through the university jobs portal.

Postdoctoral researchers are encouraged to obtain their own fellowships. Potential funding sources include:

Marie Curie Actions

Royal Society Newton International Fellowships

EMBO Fellowships

Swiss National Foundation

Human Science Frontier Programme

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