Publications

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Currently displaying 1 - 20 of 271 publications

Bifunctional Phagocytic Synapse Enhancers Remodel the Tumor Microenvironment to Overcome Immunosuppression

V Sabatino, C Tang, RC Acúrcio, AR Coelho, FM Müller, M Fontes, WT Khaw, C Labão-Almeida, DR Hicks, W Yang, A Vasco Vidal, I Sarkar, D Shome, M Cabeza-Cabrerizo, TV Rohm, S Fleisch, A Gerber, SA Hogan, F Gerster, D Kaymak, S Pantelyushin, J Vom Berg, L Li, RM Reijmers, R Fior, D Baker, HF Florindo, G Hutter, GJL Bernardes

Cancer Research

(2026)

(doi: 10.1158/0008-5472.CAN-25-5578)

Correction to “Allosteric Antagonist Modulation of TRPV2 by Piperlongumine Impairs Glioblastoma Progression”

J Conde, RA Pumroy, C Baker, T Rodrigues, A Guerreiro, B Sousa, MC Marques, BP de Almeida, S Lee, EP Leites, D Picard, A Samanta, SH Vaz, F Sieglitz, M Langini, M Remke, R Roque, T Weiss, M Weller, Y Liu, S Han, F Corzana, VA Morais, C Faria, T Carvalho, P Filippakopoulos, B Snijder, NL Barbosa-Morais, VY Moiseenkova-Bell, GJL Bernardes

ACS Central Science

(2026)

(doi: 10.1021/acscentsci.6c01291)

Postoperative Changes in Cervical Hemodynamics and Cognitive Function Following Cervical Lymphatic-Venous Surgery in Alzheimer’s Disease

X Zheng, C Tang, H Li, B Wang, Y Zheng, W Song, A Wu, L Xin, D Zhang, R Yang, S Du, P He, Y Li, L Wu, Q Shi, GJL Bernardes

Journal of Alzheimer's Disease

(2026)

112

1536

(doi: 10.1177/13872877261459037)

Dynamic palladium speciation governs prodrug activation by nanoparticles in vitro and in vivo

E Latocheski, GMD Forno, JP Agnes, J Konč, A Zanotto-Filho, GJL Bernardes, JB Domingos

Colloids and surfaces. B, Biointerfaces

(2026)

267

115902

(doi: 10.1016/j.colsurfb.2026.115902)

Regulatory T cells sabotage anti-tumor γδ T cells by creating IL-2-deficient environments

G Lopes Bernardes

Journal of Experimental Medicine

(2026)

223

e20252133

(doi: 10.1084/jem.20252133)

Glutathione-responsive fragmentation of heteronorbornadiene-based thiovinyl sulfones in glioma cells

M Carranza, AT Carmona, E Gil de Montes, Y Méndez, I Černauskienė, GJL Bernardes, AJ Moreno-Vargas

Bioconjugate Chemistry

(2026)

906

(doi: 10.1021/acs.bioconjchem.5c00581)

Selective TRPV2 Antagonists Derived from the Natural Product Piperlongumine Inhibit Cancer Cell Migration and Metastasis.

H Kiely-Collins, C Tang, MC Marques, L Butron, A Lamberti, N Bossons, F Offensperger, V Brennsteiner, B Sousa, L Carvalho, A Ferrer-Montiel, F Corzana, GE Winter, A Fernandez-Carvajal, GJL Bernardes

ACS chemical biology

(2026)

674

(doi: 10.1021/acschembio.5c00935)

A Bifunctional Small Molecule Degrader of the Long Noncoding RNA MALAT1 Triplex.

CAT Brega, BA Craig, S Mikutis, RSJ Proctor, Y Vyborna, G Ivey, M Eleftheriou, K Tzelepis, M Yang, S Parmar, J Bonet-Aleta, JS Schneekloth, GJL Bernardes

Chemistry A European Journal

(2026)

e00025

(doi: 10.1002/chem.202600025)

Deep cervical lymphatic-venous anastomosis in dementia: a clinical and mechanistic evaluation.

C Tang, X Zheng, H Li, B Wang, Y Zheng, W Song, A Wu, L Xin, D Zhang, R Yang, S Du, P He, Y Li, L Wu, X Wang, Q Shi, GJL Bernardes

International journal of surgery (London, England)

(2025)

112

9002

(doi: 10.1097/js9.0000000000004561)

Controlled Self-Immolative Release of β-Lapachone via an Optimized para-Hydroxybenzyl Linker for Targeted Pancreatic Cancer Therapy

JB Becher, N Dutta, CD Navo, L Dunsmore, R Misteli, E Gil de Montes, GG Simpson, CC Alewine, G Jiménez-Osés, GJL Bernardes

J Am Chem Soc

(2025)

147

48271

(doi: 10.1021/jacs.5c17598)

A Cathepsin B‐Triggered CO‐Releasing Molecule with a Non‐Toxic Metal Core for Targeted Tumor Delivery

I Černauskienė, E Izquierdo‐García, S Keller, H Betts, K Cariou, V Marchán, G Gasser, GJL Bernardes

Angewandte Chemie

(2025)

138

e13808

(doi: 10.1002/ange.202513808)

A Cathepsin B‐Triggered CO‐Releasing Molecule with a Non‐Toxic Metal Core for Targeted Tumor Delivery

I Černauskienė, E Izquierdo‐García, S Keller, H Betts, K Cariou, V Marchán, G Gasser, GJL Bernardes

Angewandte Chemie International Edition

(2025)

e13808

(doi: 10.1002/anie.202513808)

Advances in Proximity-Assisted Bioconjugation.

M Canzano, GJL Bernardes

Accounts of Chemical Research

(2025)

2939

(doi: 10.1021/acs.accounts.5c00368)

Tumor-Specific STING Agonist Synthesis via a Two-Component Prodrug System

N-S Hsu, C Tang, RV Mendes, C Labão-Almeida, CV Dos Reis, AR Coelho, MC Marques, M Cabeza Cabrerizo, R Misteli, TPC Rooney, M Hyvönen, F Corzana, R Fior, GJL Bernardes

Nature chemistry

(2025)

1941

(doi: 10.1038/s41557-025-01930-9)

[2.2.1]Heterobicyclic Bromovinyl Sulfones for Thiol-Triggered Strategies in Linker Chemistry: Aza- vs Oxa-Norbornadienic Systems

M Carranza, AT Carmona, C Maya, E Gil de Montes, AV Vasco, GJL Bernardes, AJ Moreno-Vargas

Bioconjugate chemistry

(2025)

2079

(doi: 10.1021/acs.bioconjchem.5c00371)

A Charge-Driven Strategy for Covalent Modification and Modulation of Biomolecular Condensates

Z Chen, L Liu, J Cattin, TPJ Knowles, GJL Bernardes

J Am Chem Soc

(2025)

147

28558

(doi: 10.1021/jacs.5c06625)

A De Novo Luciferase Bioconjugate for the Cas13-based Detection of Influenza A

M Canzano, JL Harman, Y Méndez, A Quijano-Rubio, D-A Silva, GJL Bernardes

Jacs Au

(2025)

3914

(doi: 10.1021/jacsau.5c00576)

LuxSit Pro and sPro: Next-Generation Designed Luciferases for Bioluminescent Reporting and Complementation-Based Detection

R Vergara, J Wagner, P Kamalian, JL Harman, N Lara, ES Fischer, GJL Bernardes, A Quijano-Rubio, D-A Silva

(2025)

(doi: 10.1101/2025.07.21.665742)

Immunodiagnostic plasma amino acid residue biomarkers detect cancer early and predict treatment response.

C Tang, P Corredeira, S Casimiro, Q Shi, Q Han, W Sukdao, A Cavaco, C Melo-Alvim, CO Matos, C Abreu, S Walsh, G Nogueira-Costa, L Ribeiro, R Sousa, AL Barradas, JE Fonseca, L Costa, EV Yates, GJL Bernardes

Nature communications

(2025)

6474

(doi: 10.1038/s41467-025-61685-2)

Targeted Protein Modification with an Antibody-Based System

O Rimon, J Konc, I Černauskienė, M Ali, V Roy Chowdhury, P Sormanni, GJL Bernardes, M Vendruscolo

ACS Cent Sci

(2025)

1364

(doi: 10.1021/acscentsci.5c00651)

Interested in joining the GBernardesLab?

We are always looking for enthusiastic and bright researchers to join the lab. If you are interested in joining the group, please contact Gonçalo directly at gb453@cam.ac.uk.

All applications should include a cover letter that highlights your research interests, a full CV, and the names and addresses of two referees.

Funded PhD and Postdoctoral positions will be advertised when available through the university jobs portal.

Postdoctoral researchers are encouraged to obtain their own fellowships. Potential funding sources include:

Marie Curie Actions

Royal Society Newton International Fellowships

EMBO Fellowships

Swiss National Foundation

Human Science Frontier Programme

Check out Gonçalo's Google Scholar and the groups LinkedIn for more information.