Publications

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Currently displaying 141 - 160 of 264 publications

Contemporary approaches to site-selective protein modification

EA Hoyt, PMSD Cal, BL Oliveira, GJL Bernardes

Nature Reviews Chemistry

(2019)

147

(doi: 10.1038/s41570-019-0079-1)

A Fluorogenic Probe for Cell Surface Phosphatidylserine Using an Intramolecular Indicator Displacement Sensing Mechanism

VE Zwicker, BL Oliveira, JH Yeo, ST Fraser, GJL Bernardes, EJ New, KA Jolliffe

Angewandte Chemie

(2019)

131

3119

(doi: 10.1002/ange.201812489)

Structure-Based Design of Potent Tumor-Associated Antigens: Modulation of Peptide Presentation by Single-Atom O/S or O/Se Substitutions at the Glycosidic Linkage.

I Compañón, A Guerreiro, V Mangini, J Castro-López, M Escudero-Casao, A Avenoza, JH Busto, S Castillón, J Jiménez-Barbero, JL Asensio, G Jiménez-Osés, O Boutureira, JM Peregrina, R Hurtado-Guerrero, R Fiammengo, GJL Bernardes, F Corzana

Journal of the American Chemical Society

(2019)

141

4063

(doi: 10.1021/jacs.8b13503)

De novo design of potent and selective mimics of IL-2 and IL-15.

D-A Silva, S Yu, UY Ulge, JB Spangler, KM Jude, C Labão-Almeida, LR Ali, A Quijano-Rubio, M Ruterbusch, I Leung, T Biary, SJ Crowley, E Marcos, CD Walkey, BD Weitzner, F Pardo-Avila, J Castellanos, L Carter, L Stewart, SR Riddell, M Pepper, GJL Bernardes, M Dougan, KC Garcia, D Baker

Nature

(2019)

565

186

(doi: 10.1038/s41586-018-0830-7)

Efficient and irreversible antibody–cysteine bioconjugation using carbonylacrylic reagents

B Bernardim, MJ Matos, X Ferhati, I Compañón, A Guerreiro, P Akkapeddi, ACB Burtoloso, G Jiménez-Osés, F Corzana, GJL Bernardes

Nat Protoc

(2019)

(doi: 10.1038/s41596-018-0083-9)

Lysine Bioconjugation on Native Albumin with a Sulfonyl Acrylate Reagent.

MJ Matos, G Jiménez-Osés, GJL Bernardes

Methods Mol Biol

(2019)

2033

(doi: 10.1007/978-1-4939-9654-4_3)

One-pot stapling of interchain disulfides of antibodies using an isobutylene motif.

S Sun, P Akkapeddi, MC Marques, N Martínez-Sáez, VM Torres, C Cordeiro, O Boutureira, GJL Bernardes

Organic & Biomolecular Chemistry

(2018)

2005

(doi: 10.1039/c8ob02877j)

Protein engineering through chemical, genetic and computational manipulation.

I Hamachi, GJL Bernardes

Chemical Society reviews

(2018)

8977

(doi: 10.1039/c8cs90125b)

Bioorthogonal decaging reactions for targeted drug activation

S Davies, BJ Stenton, GJL Bernardes

CHIMIA International Journal for Chemistry

(2018)

771

(doi: 10.2533/chimia.2018.771)

Radical-Mediated Thiol-Ene Strategy: Photoactivation of Thiol-Containing Drugs in Cancer Cells

GJ Lopes Bernardes

Angew Chem Int Ed Engl

(2018)

15832

(doi: 10.1002/ange.201811338)

Modular Pore-Forming Immunotoxins with Caged Cytotoxicity Tailored by Directed Evolution

NL Mutter, M Soskine, G Huang, IS Albuquerque, GJL Bernardes, G Maglia

ACS Chem Biol

(2018)

3153

(doi: 10.1021/acschembio.8b00720)

Cisplatin-Triggered Bioorthogonal Decaging of Amide Bonds for Targeted-Drug Activation in vivo

B Stenton, B Oliveira, J Conde, M Negrão, M Godinho Ferreira, R Fior, G Bernardes

(2018)

(doi: 10.26434/chemrxiv.7327904.v1)

Posttranslational Chemical Mutagenesis: To Reveal the Role of Noncatalytic Cysteine Residues in Pathogenic Bacterial Phosphatases.

JB Bertoldo, H Terenzi, S Hüttelmaier, GJL Bernardes

Biochemistry

(2018)

6144

(doi: 10.1021/acs.biochem.8b00639)

Discovery of 2,4-dimethoxypyridines as novel autophagy inhibitors

L Robke, T Rodrigues, P Schröder, DJ Foley, GJL Bernardes, L Laraia, H Waldmann

Tetrahedron

(2018)

4531

(doi: 10.1016/j.tet.2018.07.021)

Synthesis and Biological Evaluation of Homogenous Thiol-Linked NHC*–Au–Albumin and –Trastuzumab Bioconjugates

MJ Matos, C Labão-Almeida, C Sayers, O Dada, M Tacke, GJL Bernardes

Chemistry A European Journal

(2018)

12250

(doi: 10.1002/chem.201800872)

Machine intelligence decrypts β-lapachone as an allosteric 5-lipoxygenase inhibitor

T Rodrigues, M Werner, J Roth, EHG da Cruz, MC Marques, P Akkapeddi, SA Lobo, A Koeberle, F Corzana, EN da Silva Júnior, O Werz, GJL Bernardes

Chem Sci

(2018)

6899

(doi: 10.1039/c8sc02634c)

Site-selective installation of an electrophilic handle on proteins for bioconjugation.

B Lee, S Sun, E Jiménez-Moreno, AA Neves, GJL Bernardes

Bioorganic and Medicinal Chemistry

(2018)

3060

(doi: 10.1016/j.bmc.2018.02.028)

Sustainable Polysulfides for Oil Spill Remediation: Repurposing Industrial Waste for Environmental Benefit

MJH Worthington, CJ Shearer, LJ Esdaile, JA Campbell, CT Gibson, SK Legg, Y Yin, NA Lundquist, JR Gascooke, IS Albuquerque, JG Shapter, GG Andersson, DA Lewis, GJL Bernardes, JM Chalker

Advanced Sustainable Systems

(2018)

1800024

(doi: 10.1002/adsu.201800024)

Artificial Intelligence Recognizes β-Lapachone as an Allosteric 5- Lipoxygenase Inhibitor

G Bernardes, T Rodrigues, M Werner, J Roth, E da Cruz, M Marques, S Lobo, A Koeberle, F Corzana, E N. da Silva Júnior, O Werz

(2018)

(doi: 10.26434/chemrxiv.6026795.v1)

Chemo- and Regioselective Lysine Modification on Native Proteins

MJ Matos, BL Oliveira, N Martínez-Sáez, A Guerreiro, PMSD Cal, J Bertoldo, M Maneiro, E Perkins, J Howard, MJ Deery, JM Chalker, F Corzana, G Jiménez-Osés, GJL Bernardes

J Am Chem Soc

(2018)

140

4004

(doi: 10.1021/jacs.7b12874)

Interested in joining the GBernardesLab?

We are always looking for enthusiastic and bright researchers to join the lab. If you are interested in joining the group, please contact Gonçalo directly at gb453@cam.ac.uk.

All applications should include a cover letter that highlights your research interests, a full CV, and the names and addresses of two referees.

Funded PhD and Postdoctoral positions will be advertised when available through the university jobs portal.

Postdoctoral researchers are encouraged to obtain their own fellowships. Potential funding sources include:

Marie Curie Actions

Royal Society Newton International Fellowships

Fundação para a Ciência e a Tecnologia

EMBO Fellowships

Swiss National Foundation

Human Science Frontier Programme

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