Publications

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Currently displaying 61 - 80 of 264 publications

Retaining the structural integrity of disulfide bonds in diphtheria toxoid carrier protein is crucial for the effectiveness of glycoconjugate vaccine candidates.

F Carboni, A Kitowski, C Sorieul, D Veggi, MC Marques, D Oldrini, E Balducci, B Brogioni, L Del Bino, A Corrado, F Angiolini, L Dello Iacono, I Margarit, MR Romano, GJL Bernardes, R Adamo

Chem Sci

(2022)

2440

(doi: 10.1039/d1sc01928g)

Transition metal mediated bioorthogonal release

V Sabatino, VB Unnikrishnan, GJL Bernardes

Chem Catalysis

(2022)

(doi: 10.1016/j.checat.2021.12.007)

Controlled In‐Cell Generation of Active Palladium(0) Species for Bioorthogonal Decaging

J Konč, V Sabatino, E Jiménez‐Moreno, E Latocheski, LR Pérez, J Day, JB Domingos, GJL Bernardes

Angewandte Chemie

(2022)

134

e202113519

(doi: 10.1002/ange.202113519)

A structural ensemble of a tau-microtubule complex reveals regulatory tau phosphorylation and acetylation mechanisms

F Brotzakis, P Lindstedt, R Taylor, G Bernardes, M Vendruscolo

ACS Central Science

(2021)

(doi: 10.21203/rs.3.rs-215084/v1)

A Structural Ensemble of a Tau-Microtubule Complex Reveals Regulatory Tau Phosphorylation and Acetylation Mechanisms

ZF Brotzakis, PR Lindstedt, RJ Taylor, DJ Rinauro, NCT Gallagher, GJL Bernardes, M Vendruscolo

ACS Central Science

(2021)

1986

(doi: 10.1021/acscentsci.1c00585)

Diazaborines Are a Versatile Platform to Develop ROS-Responsive Antibody Drug Conjugates*.

JPM António, JI Carvalho, AS André, JNR Dias, SI Aguiar, H Faustino, RMRM Lopes, LF Veiros, GJL Bernardes, FA da Silva, PMP Gois

Angew Chem Int Ed Engl

(2021)

25914

(doi: 10.1002/anie.202109835)

Controlled In-Cell Generation of Active Palladium(0) Species for Bioorthogonal Decaging.

J Konč, V Sabatino, E Jiménez-Moreno, E Latocheski, LR Pérez, J Day, JB Domingos, GJL Bernardes

Angew Chem Int Ed Engl

(2021)

e202113519

(doi: 10.1002/anie.202113519)

A Platform for Site-Specific DNA-Antibody Bioconjugation by Using Benzoylacrylic-Labelled Oligonucleotides.

J Konč, L Brown, DR Whiten, Y Zuo, P Ravn, D Klenerman, GJL Bernardes

Angewandte Chemie International Edition

(2021)

25905

(doi: 10.1002/anie.202109713)

A Platform for Site‐Specific DNA‐Antibody Bioconjugation by Using Benzoylacrylic‐Labelled Oligonucleotides

J Konč, L Brown, DR Whiten, Y Zuo, P Ravn, D Klenerman, GJL Bernardes

Angewandte Chemie

(2021)

133

26109

(doi: 10.1002/ange.202109713)

Bioorthogonal Self-lmmolative Linker Based on Grob Fragmentation

X Ferhati, M Salas-Cubero, P Garrido, J García-Sanmartín, A Guerreiro, A Avenoza, JH Busto, JM Peregrina, A Martínez, E Jiménez-Moreno, GJL Bernardes, F Corzana

Organic letters

(2021)

8580

(doi: 10.1021/acs.orglett.1c03299)

Accelerating Reaction Rates of Biomolecules by Using Shear Stress in Artificial Capillary Systems.

TA Hakala, EV Yates, PK Challa, Z Toprakcioglu, K Nadendla, D Matak-Vinkovic, CM Dobson, R Martínez, F Corzana, TPJ Knowles, GJL Bernardes

J Am Chem Soc

(2021)

143

16401

(doi: 10.1021/jacs.1c03681)

Dichloro Butenediamides as Irreversible Site‐Selective Protein Conjugation Reagent

V Laserna, D Abegg, CF Afonso, EM Martin, A Adibekian, P Ravn, F Corzana, GJL Bernardes

Angewandte Chemie

(2021)

133

23943

(doi: 10.1002/ange.202108791)

Dichloro Butenediamides as Irreversible Site-Selective Protein Conjugation Reagent

V Laserna, D Abegg, CF Afonso, EM Martin, A Adibekian, P Ravn, F Corzana, GJL Bernardes

Angew Chem Int Ed Engl

(2021)

23750

(doi: 10.1002/anie.202108791)

Combating small-molecule aggregation with machine learning

K Lee, A Yang, YC Lin, D Reker, GJL Bernardes, T Rodrigues

Cell Reports Physical Science

(2021)

100573

(doi: 10.1016/j.xcrp.2021.100573)

METTL1-mediated m<sup>7</sup>G modification of Arg-TCT tRNA drives oncogenic transformation.

EA Orellana, Q Liu, E Yankova, M Pirouz, E De Braekeleer, W Zhang, J Lim, D Aspris, E Sendinc, DA Garyfallos, M Gu, R Ali, A Gutierrez, S Mikutis, GJL Bernardes, ES Fischer, A Bradley, GS Vassiliou, FJ Slack, K Tzelepis, RI Gregory

Molecular Cell

(2021)

3323

(doi: 10.1016/j.molcel.2021.06.031)

Exploration of Long-Chain Vitamin E Metabolites for the Discovery of a Highly Potent, Orally Effective, and Metabolically Stable 5‑LOX Inhibitor that Limits Inflammation

K Neukirch, K Alsabil, C-P Dinh, R Bilancia, M Raasch, A Ville, I Cerqua, G Viault, D Bréard, S Pace, V Temml, E Brunner, PM Jordan, MC Marques, K Loeser, A Gollowitzer, S Permann, J Gerstmeier, S Lorkowski, H Stuppner, U Garscha, T Rodrigues, GJL Bernardes, D Schuster, D Séraphin, P Richomme, A Rossi, AS Mosig, F Roviezzo, O Werz, J-J Helesbeux, A Koeberle

J Med Chem

(2021)

11496

(doi: 10.1021/acs.jmedchem.1c00806)

Arylethynyltrifluoroborate Dienophiles for On Demand Activation of IEDDA Reactions

Z Zawada, Z Guo, BL Oliveira, CD Navo, H Li, PMSD Cal, F Corzana, G Jiménez-Osés, GJL Bernardes

Bioconjugate chemistry

(2021)

1812

(doi: 10.1021/acs.bioconjchem.1c00276)

Protein Conjugation by Electrophilic Alkynylation Using 5‑(Alkynyl)dibenzothiophenium Triflates

V Laserna, A Istrate, K Kafuta, TA Hakala, TPJ Knowles, M Alcarazo, GJL Bernardes

Bioconjugate Chemistry

(2021)

1570

(doi: 10.1021/acs.bioconjchem.1c00317)

Allosteric Antagonist Modulation of TRPV2 by Piperlongumine Impairs Glioblastoma Progression

J Conde, RA Pumroy, C Baker, T Rodrigues, A Guerreiro, BB Sousa, MC Marques, BP de Almeida, S Lee, EP Leites, D Picard, A Samanta, SH Vaz, F Sieglitz, M Langini, M Remke, R Roque, T Weiss, M Weller, Y Liu, S Han, F Corzana, VA Morais, CC Faria, T Carvalho, P Filippakopoulos, B Snijder, NL Barbosa-Morais, VY Moiseenkova-Bell, GJL Bernardes

ACS Cent Sci

(2021)

868

(doi: 10.1021/acscentsci.1c00070)

The role of reversible and irreversible covalent chemistry in targeted protein degradation.

H Kiely-Collins, GE Winter, GJL Bernardes

Cell chemical biology

(2021)

952

(doi: 10.1016/j.chembiol.2021.03.005)

Interested in joining the GBernardesLab?

We are always looking for enthusiastic and bright researchers to join the lab. If you are interested in joining the group, please contact Gonçalo directly at gb453@cam.ac.uk.

All applications should include a cover letter that highlights your research interests, a full CV, and the names and addresses of two referees.

Funded PhD and Postdoctoral positions will be advertised when available through the university jobs portal.

Postdoctoral researchers are encouraged to obtain their own fellowships. Potential funding sources include:

Marie Curie Actions

Royal Society Newton International Fellowships

Fundação para a Ciência e a Tecnologia

EMBO Fellowships

Swiss National Foundation

Human Science Frontier Programme

Check out Gonçalo's Google Scholar and the groups LinkedIn for more information.