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Currently displaying 61 - 80 of 261 publications

Controlled In-Cell Generation of Active Palladium(0) Species for Bioorthogonal Decaging.

J Konč, V Sabatino, E Jiménez-Moreno, E Latocheski, LR Pérez, J Day, JB Domingos, GJL Bernardes

Angewandte Chemie (International ed. in English)

(2021)

e202113519

(doi: 10.1002/anie.202113519)

Diazaborines Are a Versatile Platform to Develop ROS‐Responsive Antibody Drug Conjugates**

JPM António, JI Carvalho, AS André, JNR Dias, SI Aguiar, H Faustino, RMRM Lopes, LF Veiros, GJL Bernardes, FA da Silva, PMP Gois

Angew Chem Int Ed Engl

(2021)

25914

(doi: 10.1002/anie.202109835)

A Platform for Site‐Specific DNA‐Antibody Bioconjugation by Using Benzoylacrylic‐Labelled Oligonucleotides

J Konč, L Brown, DR Whiten, Y Zuo, P Ravn, D Klenerman, GJL Bernardes

Angewandte Chemie (International ed. in English)

(2021)

25905

(doi: 10.1002/anie.202109713)

A Platform for Site‐Specific DNA‐Antibody Bioconjugation by Using Benzoylacrylic‐Labelled Oligonucleotides

J Konč, L Brown, DR Whiten, Y Zuo, P Ravn, D Klenerman, GJL Bernardes

Angewandte Chemie

(2021)

133

26109

(doi: 10.1002/ange.202109713)

Bioorthogonal Self-Immolative Linker Based on Grob Fragmentation.

X Ferhati, M Salas-Cubero, P Garrido, J García-Sanmartín, A Guerreiro, A Avenoza, JH Busto, JM Peregrina, A Martínez, E Jiménez-Moreno, GJL Bernardes, F Corzana

Organic letters

(2021)

8580

(doi: 10.1021/acs.orglett.1c03299)

Accelerating Reaction Rates of Biomolecules by Using Shear Stress in Artificial Capillary Systems

TA Hakala, EV Yates, PK Challa, Z Toprakcioglu, K Nadendla, D Matak-Vinkovic, CM Dobson, R Martínez, F Corzana, TPJ Knowles, GJL Bernardes

J Am Chem Soc

(2021)

143

16401

(doi: 10.1021/jacs.1c03681)

Dichloro Butenediamides as Irreversible Site-Selective Protein Conjugation Reagent.

V Laserna, D Abegg, CF Afonso, EM Martin, A Adibekian, P Ravn, F Corzana, GJL Bernardes

Angew Chem Int Ed Engl

(2021)

23750

(doi: 10.1002/anie.202108791)

Dichloro Butenediamides as Irreversible Site‐Selective Protein Conjugation Reagent

V Laserna, D Abegg, CF Afonso, EM Martin, A Adibekian, P Ravn, F Corzana, GJL Bernardes

Angewandte Chemie

(2021)

133

23943

(doi: 10.1002/ange.202108791)

Combating small-molecule aggregation with machine learning

K Lee, A Yang, YC Lin, D Reker, GJL Bernardes, T Rodrigues

Cell Reports Physical Science

(2021)

100573

(doi: 10.1016/j.xcrp.2021.100573)

METTL1-mediated m7G modification of Arg-TCT tRNA drives oncogenic transformation

EA Orellana, Q Liu, E Yankova, M Pirouz, E De Braekeleer, W Zhang, J Lim, D Aspris, E Sendinc, DA Garyfallos, M Gu, R Ali, A Gutierrez, S Mikutis, GJL Bernardes, ES Fischer, A Bradley, GS Vassiliou, FJ Slack, K Tzelepis, RI Gregory

Molecular cell

(2021)

3323

(doi: 10.1016/j.molcel.2021.06.031)

Exploration of Long-Chain Vitamin e Metabolites for the Discovery of a Highly Potent, Orally Effective, and Metabolically Stable 5-LOX Inhibitor that Limits Inflammation

K Neukirch, K Alsabil, C-P Dinh, R Bilancia, M Raasch, A Ville, I Cerqua, G Viault, D Bréard, S Pace, V Temml, E Brunner, PM Jordan, MC Marques, K Loeser, A Gollowitzer, S Permann, J Gerstmeier, S Lorkowski, H Stuppner, U Garscha, T Rodrigues, GJL Bernardes, D Schuster, D Séraphin, P Richomme, A Rossi, AS Mosig, F Roviezzo, O Werz, J-J Helesbeux, A Koeberle

J Med Chem

(2021)

11496

(doi: 10.1021/acs.jmedchem.1c00806)

Arylethynyltrifluoroborate Dienophiles for On Demand Activation of IEDDA Reactions

Z Zawada, Z Guo, BL Oliveira, CD Navo, H Li, PMSD Cal, F Corzana, G Jiménez-Osés, GJL Bernardes

Bioconjugate chemistry

(2021)

1812

(doi: 10.1021/acs.bioconjchem.1c00276)

Protein Conjugation by Electrophilic Alkynylation Using 5-(Alkynyl)dibenzothiophenium Triflates

V Laserna, A Istrate, K Kafuta, TA Hakala, TPJ Knowles, M Alcarazo, GJL Bernardes

Bioconjugate chemistry

(2021)

1570

(doi: 10.1021/acs.bioconjchem.1c00317)

Allosteric Antagonist Modulation of TRPV2 by Piperlongumine Impairs Glioblastoma Progression.

J Conde, RA Pumroy, C Baker, T Rodrigues, A Guerreiro, BB Sousa, MC Marques, BP de Almeida, S Lee, EP Leites, D Picard, A Samanta, SH Vaz, F Sieglitz, M Langini, M Remke, R Roque, T Weiss, M Weller, Y Liu, S Han, F Corzana, VA Morais, CC Faria, T Carvalho, P Filippakopoulos, B Snijder, NL Barbosa-Morais, VY Moiseenkova-Bell, GJL Bernardes

ACS central science

(2021)

868

(doi: 10.1021/acscentsci.1c00070)

The role of reversible and irreversible covalent chemistry in targeted protein degradation.

H Kiely-Collins, GE Winter, GJL Bernardes

Cell chemical biology

(2021)

952

(doi: 10.1016/j.chembiol.2021.03.005)

Precise protein conjugation technology for the construction of homogenous glycovaccines.

A Kitowski, F Corzana, GJL Bernardes

Drug Discovery Today: Technologies

(2021)

(doi: 10.1016/j.ddtec.2020.11.007)

Fragment-based computational design of antibodies targeting structured epitopes

MA Rangel, A Bedwell, E Costanzi, R Taylor, R Russo, G Bernardes, S Ricagno, J Frydman, M Vendruscolo, P Sormanni

(2021)

2021.03.02.433360

(doi: 10.1101/2021.03.02.433360)

Facile Installation of Post-translational Modifications on the Tau Protein via Chemical Mutagenesis.

PR Lindstedt, RJ Taylor, GJL Bernardes, M Vendruscolo

ACS Chem Neurosci

(2021)

557

(doi: 10.1021/acschemneuro.0c00761)

TRPV2 Modulation by Small Molecules and Lipids

AD Protopopova, RA Pumroy, J de la Roche, FM Haug, BB Sousa, PN Gallo, GJL Bernardes, A Leffler, VY Moiseenkova-Bell

BIOPHYSICAL JOURNAL

(2021)

120

112A

In Vivo Pretargeting Based on Cysteine-Selective Antibody Modification with IEDDA Bioorthogonal Handles for Click Chemistry.

VFC Ferreira, BL Oliveira, A D'Onofrio, CM Farinha, L Gano, A Paulo, GJL Bernardes, F Mendes

Bioconjug Chem

(2020)

121

(doi: 10.1021/acs.bioconjchem.0c00551)

Interested in joining the GBernardesLab?

We are always looking for enthusiastic and bright researchers to join the lab. If you are interested in joining the group, please contact Gonçalo directly at gb453@cam.ac.uk.

All applications should include a cover letter that highlights your research interests, a full CV, and the names and addresses of two referees.

Funded PhD and Postdoctoral positions will be advertised when available through the university jobs portal.

Postdoctoral researchers are encouraged to obtain their own fellowships. Potential funding sources include:

Marie Curie Actions

Royal Society Newton International Fellowships

Fundação para a Ciência e a Tecnologia

EMBO Fellowships

Swiss National Foundation

Human Science Frontier Programme