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Currently displaying 61 - 80 of 266 publications

Controlled masking and targeted release of redox-cycling ortho-quinones via a C–C bond-cleaving 1,6-elimination

L Dunsmore, CD Navo, J Becher, EG de Montes, A Guerreiro, E Hoyt, L Brown, V Zelenay, S Mikutis, J Cooper, I Barbieri, S Lawrinowitz, E Siouve, E Martin, PR Ruivo, T Rodrigues, FP da Cruz, O Werz, G Vassiliou, P Ravn, G Jiménez-Osés, GJL Bernardes

Nature Chemistry

(2022)

754

(doi: 10.1038/s41557-022-00964-7)

Platform for Orthogonal N‑Cysteine-Specific Protein Modification Enabled by Cyclopropenone Reagents

A Istrate, MB Geeson, CD Navo, BB Sousa, MC Marques, RJ Taylor, T Journeaux, SR Oehler, MR Mortensen, MJ Deery, AD Bond, F Corzana, G Jiménez-Osés, GJL Bernardes

J Am Chem Soc

(2022)

144

10396

(doi: 10.1021/jacs.2c02185)

The Impact of Activity-based Protein Profiling in Malaria Drug Discovery.

LAR Carvalho, GJL Bernardes

ChemMedChem

(2022)

e202200174

(doi: 10.1002/cmdc.202200174)

Structural insights into TRPV2 activation by small molecules

RA Pumroy, AD Protopopova, TC Fricke, IU Lange, FM Haug, PT Nguyen, PN Gallo, BB Sousa, G Lopes Bernardes, V Yarov-Yarovoy, A Leffler, VY Moiseenkova-Bell

Nature Communications

(2022)

(doi: 10.1038/s41467-022-30083-3)

Ibrutinib Inhibits BMX-Dependent Endothelial VCAM-1 Expression In Vitro and Pro-Atherosclerotic Endothelial Activation and Platelet Adhesion In Vivo.

TCL Kohs, SR Olson, J Pang, KR Jordan, TJ Zheng, A Xie, J Hodovan, M Muller, C McArthur, J Johnson, BB Sousa, M Wallisch, P Kievit, JE Aslan, JD Seixas, GJL Bernardes, MT Hinds, JR Lindner, OJT McCarty, C Puy, JJ Shatzel

Cellular and molecular bioengineering

(2022)

231

(doi: 10.1007/s12195-022-00723-1)

Single Mutation on Trastuzumab Modulates the Stability of Antibody-Drug Conjugates Built Using Acetal-Based Linkers and Thiol-Maleimide Chemistry

X Ferhati, E Jiménez-Moreno, EA Hoyt, G Salluce, M Cabeza-Cabrerizo, CD Navo, I Compañón, P Akkapeddi, MJ Matos, N Salaverri, P Garrido, A Martínez, V Laserna, TV Murray, G Jiménez-Osés, P Ravn, GJL Bernardes, F Corzana

J Am Chem Soc

(2022)

144

5284

(doi: 10.1021/jacs.1c07675)

Retaining the structural integrity of disulfide bonds in diphtheria toxoid carrier protein is crucial for effectiveness of glycoconjugate vaccine candidates

G Lopes Bernardes, F carboni, A kitowski, C Sorieul, D Veggi, M Marques, D Oldrini, E Balducci, B Brogioni, L Del Bino, A Corrado, F Angiolini, L Dello Iacono, I Margarit, M Romano, R Adamo

Chemical Science

(2022)

(doi: 10.1039/D1SC01928G)

Retaining the structural integrity of disulfide bonds in diphtheria toxoid carrier protein is crucial for the effectiveness of glycoconjugate vaccine candidates

F Carboni, A Kitowski, C Sorieul, D Veggi, MC Marques, D Oldrini, E Balducci, B Brogioni, L Del Bino, A Corrado, F Angiolini, L Dello Iacono, I Margarit, MR Romano, GJL Bernardes, R Adamo

Chem Sci

(2022)

2440

(doi: 10.1039/d1sc01928g)

Transition metal mediated bioorthogonal release

V Sabatino, VB Unnikrishnan, GJL Bernardes

Chem Catalysis

(2022)

(doi: 10.1016/j.checat.2021.12.007)

Controlled In‐Cell Generation of Active Palladium(0) Species for Bioorthogonal Decaging

J Konč, V Sabatino, E Jiménez‐Moreno, E Latocheski, LR Pérez, J Day, JB Domingos, GJL Bernardes

Angewandte Chemie

(2022)

134

e202113519

(doi: 10.1002/ange.202113519)

A Structural Ensemble of a Tau-Microtubule Complex Reveals Regulatory Tau Phosphorylation and Acetylation Mechanisms

ZF Brotzakis, PR Lindstedt, RJ Taylor, DJ Rinauro, NCT Gallagher, GJL Bernardes, M Vendruscolo

ACS central science

(2021)

1986

(doi: 10.1021/acscentsci.1c00585)

Controlled In‐Cell Generation of Active Palladium(0) Species for Bioorthogonal Decaging

J Konč, V Sabatino, E Jiménez-Moreno, E Latocheski, LR Pérez, J Day, JB Domingos, GJL Bernardes

Angewandte Chemie (International ed. in English)

(2021)

e202113519

(doi: 10.1002/anie.202113519)

Diazaborines Are a Versatile Platform to Develop ROS-Responsive Antibody Drug Conjugates*.

JPM António, JI Carvalho, AS André, JNR Dias, SI Aguiar, H Faustino, RMRM Lopes, LF Veiros, GJL Bernardes, FA da Silva, PMP Gois

Angewandte Chemie (International ed. in English)

(2021)

25914

(doi: 10.1002/anie.202109835)

A Platform for Site-Specific DNA-Antibody Bioconjugation by Using Benzoylacrylic-Labelled Oligonucleotides

J Konč, L Brown, DR Whiten, Y Zuo, P Ravn, D Klenerman, GJL Bernardes

Angewandte Chemie (International ed. in English)

(2021)

25905

(doi: 10.1002/anie.202109713)

A Platform for Site‐Specific DNA‐Antibody Bioconjugation by Using Benzoylacrylic‐Labelled Oligonucleotides

J Konč, L Brown, DR Whiten, Y Zuo, P Ravn, D Klenerman, GJL Bernardes

Angewandte Chemie

(2021)

133

26109

(doi: 10.1002/ange.202109713)

Bioorthogonal Self-Immolative Linker Based on Grob Fragmentation

X Ferhati, M Salas-Cubero, P Garrido, J García-Sanmartín, A Guerreiro, A Avenoza, JH Busto, JM Peregrina, A Martínez, E Jiménez-Moreno, GJL Bernardes, F Corzana

Organic Letters

(2021)

8580

(doi: 10.1021/acs.orglett.1c03299)

Accelerating reaction rates of biomolecules by using shear stress in artificial capillary systems

TA Hakala, EV Yates, PK Challa, Z Toprakcioglu, K Nadendla, D Matak-Vinkovic, CM Dobson, R Martínez, F Corzana, TPJ Knowles, GJL Bernardes

Journal of the American Chemical Society

(2021)

143

16401

(doi: 10.1021/jacs.1c03681)

Dichloro Butenediamides as Irreversible Site‐Selective Protein Conjugation Reagent

V Laserna, D Abegg, CF Afonso, EM Martin, A Adibekian, P Ravn, F Corzana, GJL Bernardes

Angewandte Chemie

(2021)

133

23943

(doi: 10.1002/ange.202108791)

Dichloro Butenediamides as Irreversible Site-Selective Protein Conjugation Reagent

V Laserna, D Abegg, CF Afonso, EM Martin, A Adibekian, P Ravn, F Corzana, GJL Bernardes

Angew Chem Int Ed Engl

(2021)

23750

(doi: 10.1002/anie.202108791)

Combating small-molecule aggregation with machine learning

K Lee, A Yang, Y-C Lin, D Reker, GJL Bernardes, T Rodrigues

Cell Reports Physical Science

(2021)

100573

(doi: 10.1016/j.xcrp.2021.100573)

Interested in joining the GBernardesLab?

We are always looking for enthusiastic and bright researchers to join the lab. If you are interested in joining the group, please contact Gonçalo directly at gb453@cam.ac.uk.

All applications should include a cover letter that highlights your research interests, a full CV, and the names and addresses of two referees.

Funded PhD and Postdoctoral positions will be advertised when available through the university jobs portal.

Postdoctoral researchers are encouraged to obtain their own fellowships. Potential funding sources include:

Marie Curie Actions

Royal Society Newton International Fellowships

EMBO Fellowships

Swiss National Foundation

Human Science Frontier Programme

Check out Gonçalo's Google Scholar and the groups LinkedIn for more information.