Publications

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Currently displaying 61 - 80 of 252 publications

Dichloro Butenediamides as Irreversible Site‐Selective Protein Conjugation Reagent

V Laserna, D Abegg, CF Afonso, EM Martin, A Adibekian, P Ravn, F Corzana, GJL Bernardes

Angew Chem Int Ed Engl

(2021)

23750

(doi: 10.1002/anie.202108791)

Combating small-molecule aggregation with machine learning

K Lee, A Yang, YC Lin, D Reker, GJL Bernardes, T Rodrigues

Cell Reports Physical Science

(2021)

100573

(doi: 10.1016/j.xcrp.2021.100573)

METTL1-mediated m7G modification of Arg-TCT tRNA drives oncogenic transformation.

EA Orellana, Q Liu, E Yankova, M Pirouz, E De Braekeleer, W Zhang, J Lim, D Aspris, E Sendinc, DA Garyfallos, M Gu, R Ali, A Gutierrez, S Mikutis, GJL Bernardes, ES Fischer, A Bradley, GS Vassiliou, FJ Slack, K Tzelepis, RI Gregory

Mol Cell

(2021)

3323

(doi: 10.1016/j.molcel.2021.06.031)

Exploration of Long-Chain Vitamin E Metabolites for the Discovery of a Highly Potent, Orally Effective, and Metabolically Stable 5‑LOX Inhibitor that Limits Inflammation

K Neukirch, K Alsabil, C-P Dinh, R Bilancia, M Raasch, A Ville, I Cerqua, G Viault, D Bréard, S Pace, V Temml, E Brunner, PM Jordan, MC Marques, K Loeser, A Gollowitzer, S Permann, J Gerstmeier, S Lorkowski, H Stuppner, U Garscha, T Rodrigues, GJL Bernardes, D Schuster, D Séraphin, P Richomme, A Rossi, AS Mosig, F Roviezzo, O Werz, J-J Helesbeux, A Koeberle

J Med Chem

(2021)

11496

(doi: 10.1021/acs.jmedchem.1c00806)

Arylethynyltrifluoroborate Dienophiles for On Demand Activation of IEDDA Reactions

Z Zawada, Z Guo, BL Oliveira, CD Navo, H Li, PMSD Cal, F Corzana, G Jiménez-Osés, GJL Bernardes

Bioconjugate Chemistry

(2021)

1812

(doi: 10.1021/acs.bioconjchem.1c00276)

Protein Conjugation by Electrophilic Alkynylation Using 5-(Alkynyl)dibenzothiophenium Triflates

V Laserna, A Istrate, K Kafuta, TA Hakala, TPJ Knowles, M Alcarazo, GJL Bernardes

Bioconjugate Chemistry

(2021)

1570

(doi: 10.1021/acs.bioconjchem.1c00317)

Allosteric Antagonist Modulation of TRPV2 by Piperlongumine Impairs Glioblastoma Progression.

J Conde, RA Pumroy, C Baker, T Rodrigues, A Guerreiro, BB Sousa, MC Marques, BP de Almeida, S Lee, EP Leites, D Picard, A Samanta, SH Vaz, F Sieglitz, M Langini, M Remke, R Roque, T Weiss, M Weller, Y Liu, S Han, F Corzana, VA Morais, CC Faria, T Carvalho, P Filippakopoulos, B Snijder, NL Barbosa-Morais, VY Moiseenkova-Bell, GJL Bernardes

ACS Cent Sci

(2021)

868

(doi: 10.1021/acscentsci.1c00070)

The role of reversible and irreversible covalent chemistry in targeted protein degradation.

H Kiely-Collins, GE Winter, GJL Bernardes

Cell chemical biology

(2021)

952

(doi: 10.1016/j.chembiol.2021.03.005)

Precise Protein Conjugation Technology for the Construction of Homogenous Glycovaccines

A Kitowski, F Corzana, GJL Bernardes

Drug discovery today. Technologies

(2021)

(doi: 10.1016/j.ddtec.2020.11.007)

Facile Installation of Post-translational Modifications on the Tau Protein via Chemical Mutagenesis

PR Lindstedt, RJ Taylor, GJL Bernardes, M Vendruscolo

ACS Chem Neurosci

(2021)

557

(doi: 10.1021/acschemneuro.0c00761)

TRPV2 Modulation by Small Molecules and Lipids

AD Protopopova, RA Pumroy, J de la Roche, FM Haug, BB Sousa, PN Gallo, GJL Bernardes, A Leffler, VY Moiseenkova-Bell

BIOPHYSICAL JOURNAL

(2021)

120

112A

Multi-scale microporous silica microcapsules from gas-in water-in oil emulsions (vol 16, pg 3586, 2020)

Z Toprakcioglu, TA Hakala, A Levin, CFW Becker, GJL Bernardes, TPJ Knowles

Soft Matter

(2020)

201

(doi: 10.1039/d0sm90246b)

In Vivo Pretargeting Based on Cysteine-Selective Antibody Modification with IEDDA Bioorthogonal Handles for Click Chemistry.

VFC Ferreira, BL Oliveira, A D'Onofrio, CM Farinha, L Gano, A Paulo, GJL Bernardes, F Mendes

Bioconjugate chemistry

(2020)

121

(doi: 10.1021/acs.bioconjchem.0c00551)

Systematic Activity Maturation of a Single-Domain Antibody with Non-Canonical Amino Acids through Chemical Mutagenesis

PR Lindstedt, FA Aprile, P Sormanni, R Rakoto, CM Dobson, GJL Bernardes, M Vendruscolo

Cell Chem Biol

(2020)

(doi: 10.1016/j.chembiol.2020.11.002)

Adaptive Optimization of Chemical Reactions with Minimal Experimental Information

D Reker, EA Hoyt, GJL Bernardes, T Rodrigues

Cell Reports Physical Science

(2020)

100247

(doi: 10.1016/j.xcrp.2020.100247)

Adaptive Optimization of Chemical Reactions with Minimal Experimental Information

G Lopes Bernardes

Cell Reports Physical Science

(2020)

(doi: 10.1016/j.xcrp.2020.100247)

Structural Characterization of an Unprecedented Lectin-like Antitumoral anti-MUC1 Antibody

J Macías-León, IA Bermejo, A Asín, A García-García, I Compañón, E Jiménez-Moreno, H Coelho, V Mangini, IS Albuquerque, F Marcelo, JL Asensio, GJL Bernardes, HJ Joshi, R Fiammengo, O Blixt, R Hurtado-Guerrero, F Corzana

Chem Commun (Camb)

(2020)

15137

(doi: 10.1039/d0cc06349e)

A Structural Ensemble of a Tau-Microtubule Complex Reveals Regulatory Tau Phosphorylation and Acetylation Mechanisms

F Brotzakis, P Lindstedt, R Taylor, G Bernardes, M Vendruscolo

biorxiv

(2020)

2020.11.10.376285

(doi: 10.1101/2020.11.10.376285)

Structure of a protective epitope reveals the importance of acetylation of Neisseria meningitidis serogroup A capsular polysaccharide.

P Henriques, L Dello Iacono, A Gimeno, A Biolchi, MR Romano, A Arda, GJL Bernardes, J Jimenez-Barbero, F Berti, R Rappuoli, R Adamo

Proceedings of the National Academy of Sciences

(2020)

117

29795

(doi: 10.1073/pnas.2011385117)

MeCLICK-Seq, a Substrate-Hijacking and RNA Degradation Strategy for the Study of RNA Methylation

S Mikutis, M Gu, E Sendinc, ME Hazemi, H Kiely-Collins, D Aspris, GS Vassiliou, Y Shi, K Tzelepis, GJL Bernardes

ACS Cent Sci

(2020)

2196

(doi: 10.1021/acscentsci.0c01094)

Interested in joining the GBernardesLab?

We are always looking for enthusiastic and bright researchers to join the lab. If you are interested in joining the group, please contact Gonçalo directly at gb453@cam.ac.uk.

All applications should include a cover letter that highlights your research interests, a full CV, and the names and addresses of two referees.

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Postdoctoral researchers are encouraged to obtain their own fellowships. Potential funding sources include:

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