The Bernardes Group

Publications

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  • Currently displaying 21 - 40 of 260 publications
Author(s)
Publication title
Journal Name
Publication year
Non‐natural MUC1 Glycopeptide Homogeneous Cancer Vaccine with Enhanced Immunogenicity and Therapeutic Activity
A Guerreiro, I Compañón, FS Lazaris, C Labão-Almeida, P Oroz, M Ghirardello, MC Marques, F Corzana, GJL Bernardes
Angewandte Chemie International Edition
(2024)
63
(doi: 10.1002/anie.202411009)
Small Molecule RNA Degraders
J Bonet-Aleta, T Maehara, BA Craig, GJL Bernardes
Angew Chem Int Ed Engl
(2024)
63
(doi: 10.1002/anie.202412925)
Designed endocytosis-inducing proteins degrade targets and amplify signals.
B Huang, M Abedi, G Ahn, B Coventry, I Sappington, C Tang, R Wang, T Schlichthaerle, JZ Zhang, Y Wang, I Goreshnik, CW Chiu, A Chazin-Gray, S Chan, S Gerben, A Murray, S Wang, J O'Neill, L Yi, R Yeh, A Misquith, A Wolf, LM Tomasovic, DI Piraner, MJ Duran Gonzalez, NR Bennett, P Venkatesh, M Ahlrichs, C Dobbins, W Yang, X Wang, DD Sahtoe, D Vafeados, R Mout, S Shivaei, L Cao, L Carter, L Stewart, JB Spangler, KT Roybal, PJ Greisen, X Li, GJL Bernardes, CR Bertozzi, D Baker
Nature
(2024)
638
(doi: 10.1038/s41586-024-07948-2)
Proximity-driven site-specific cyclization of phage-displayed peptides.
L Brown, AV Vidal, AL Dias, T Rodrigues, A Sigurdardottir, T Journeaux, S O'Brien, TV Murray, P Ravn, M Papworth, GJL Bernardes
Nature Communications
(2024)
15
(doi: 10.1038/s41467-024-51610-4)
Gold (III)-Induced Amide Bond Cleavage In Vivo: A Dual Release Strategy via π-acid Mediated Allyl Substitution
VB Unnikrishnan, V Sabatino, F Amorim, MF Estrada, CD Navo, G Jimenez-Oses, R Fior, GJL Bernardes
Journal of the American Chemical Society
(2024)
146
(doi: 10.1021/jacs.4c05582)
On-Demand Thio-Succinimide Hydrolysis for the Assembly of Stable Protein–Protein Conjugates
AV Vasco, RJ Taylor, Y Méndez, GJL Bernardes
Journal of the American Chemical Society
(2024)
146
(doi: 10.1021/jacs.4c03721)
Homogeneous multi-payload antibody–drug conjugates
T Journeaux, GJL Bernardes
Nature chemistry
(2024)
16
(doi: 10.1038/s41557-024-01507-y)
Targeted protein editing with an antibody-based system
M Vendruscolo, O Rimon, J Konc, M Ali, VR Chowdhury, P Sormanni, G Bernardes
(2024)
(doi: 10.21203/rs.3.rs-3947849/v1)
Cathepsin B Processing Is Required for the In Vivo Efficacy of Albumin–Drug Conjugates
B Bernardim, J Conde, T Hakala, JB Becher, M Canzano, AV Vasco, TPJ Knowles, J Cameron, GJL Bernardes
Bioconjug Chem
(2024)
35
(doi: 10.1021/acs.bioconjchem.3c00478)
Design and Evaluation of PROTACs Targeting Acyl Protein Thioesterase 1
G Lopes Bernardes
Chembiochem : a European journal of chemical biology
(2024)
25
(doi: 10.1002/cbic.202300736)
Machine Learning Uncovers Natural Product Modulators of the 5-Lipoxygenase Pathway and Facilitates the Elucidation of Their Biological Mechanisms.
S Mikutis, S Lawrinowitz, C Kretzer, L Dunsmore, L Sketeris, T Rodrigues, O Werz, GJL Bernardes
ACS Chemical Biology
(2023)
19
(doi: 10.1021/acschembio.3c00725)
Structure-Guided Approach for the Development of MUC1-Glycopeptide-Based Cancer Vaccines with Predictable Responses.
IA Bermejo, A Guerreiro, A Eguskiza, N Martínez-Sáez, FS Lazaris, A Asín, VJ Somovilla, I Compañón, TK Raju, S Tadic, P Garrido, J García-Sanmartín, V Mangini, AS Grosso, F Marcelo, A Avenoza, JH Busto, F García-Martín, R Hurtado-Guerrero, JM Peregrina, GJL Bernardes, A Martínez, R Fiammengo, F Corzana
Jacs Au
(2023)
4
(doi: 10.1021/jacsau.3c00587)
Multiplexed Digital Characterization of Misfolded Protein Oligomers via Solid-State Nanopores.
SE Sandler, RI Horne, S Rocchetti, R Novak, N-S Hsu, M Castellana Cruz, Z Faidon Brotzakis, RC Gregory, S Chia, GJL Bernardes, UF Keyser, M Vendruscolo
J Am Chem Soc
(2023)
145
(doi: 10.1021/jacs.3c09335)
Merging the Isonitrile-Tetrazine (4+1) Cycloaddition and the Ugi Four-Component Reaction into a Single Multicomponent Process.
Y Méndez, AV Vasco, G Ivey, AL Dias, P Gierth, BB Sousa, CD Navo, A Torres-Mozas, T Rodrigues, G Jiménez-Osés, GJL Bernardes
Angew Chem Int Ed Engl
(2023)
62
(doi: 10.1002/anie.202311186)
Merging the Isonitrile‐Tetrazine (4+1) Cycloaddition and the Ugi Four‐Component Reaction into a Single Multicomponent Process
Y Méndez, AV Vasco, G Ivey, AL Dias, P Gierth, BB Sousa, CD Navo, A Torres‐Mozas, T Rodrigues, G Jiménez‐Osés, GJL Bernardes
Angewandte Chemie
(2023)
135
(doi: 10.1002/ange.202311186)
Designed Endocytosis-Triggering Proteins mediate Targeted Degradation.
B Huang, M Abedi, G Ahn, B Coventry, I Sappington, R Wang, T Schlichthaerle, JZ Zhang, Y Wang, I Goreshnik, CW Chiu, A Chazin-Gray, S Chan, S Gerben, A Murray, S Wang, J O'Neill, R Yeh, A Misquith, A Wolf, LM Tomasovic, DI Piraner, MJD Gonzalez, NR Bennett, P Venkatesh, D Satoe, M Ahlrichs, C Dobbins, W Yang, X Wang, D Vafeados, R Mout, S Shivaei, L Cao, L Carter, L Stewart, JB Spangler, GJL Bernardes, KT Roybal, P Greisen, X Li, C Bertozzi, D Baker
bioRxiv
(2023)
4
(doi: 10.1101/2023.08.19.553321)
Multiplexed Digital Characterisation of Misfolded Protein Oligomers via Solid-State Nanopores
SE Sandler, RI Horne, S Rocchetti, R Novak, N-S Hsu, MC Cruz, ZF Brotzakis, RC Gregory, S Chia, GJL Bernardes, UF Keyser, M Vendruscolo
(2023)
(doi: 10.1101/2023.08.09.552642)
Targeted protein modification with an antibody-based system
O Rimon, J Konc, M Ali, VR Chowdhury, I Černauskienė, P Sormanni, GJL Bernardes, M Vendruscolo
(2023)
(doi: 10.1101/2023.07.28.551006)
De Novo Human Angiotensin-Converting Enzyme 2 Decoy NL-CVX1 Protects Mice From Severe Disease After Severe Acute Respiratory Syndrome Coronavirus 2 Infection.
M Rebelo, C Tang, AR Coelho, C Labão-Almeida, MM Schneider, L Tatalick, P Ruivo, MP de Miranda, A Gomes, T Carvalho, MJ Walker, H Ausserwoeger, J Pedro Simas, M Veldhoen, TPJ Knowles, D-A Silva, D Shoultz, GJL Bernardes
The Journal of infectious diseases
(2023)
228
(doi: 10.1093/infdis/jiad135)
Unlocking the Potential of Bio-Based Nitrogen-Rich Furanic Platforms as Biomass Synthons
RFA Gomes, BMF Gonçalves, KHS Andrade, BB Sousa, N Maulide, GJL Bernardes, CAM Afonso
Angewandte Chemie International Edition
(2023)
62
(doi: 10.1002/anie.202304449)

Interested in joining the GBernardesLab?

We are always looking for enthusiastic and bright researchers to join the lab. If you are interested in joining the group, please contact Gonçalo directly at gb453@cam.ac.uk.

All applications should include a cover letter that highlights your research interests, a full CV, and the names and addresses of two referees.

Funded PhD and Postdoctoral positions will be advertised when available through the university jobs portal. 

Postdoctoral researchers are encouraged to obtain their own fellowships. Potential funding sources include:

Marie Curie Actions

Royal Society Newton International Fellowships

Fundação para a Ciência e a Tecnologia

EMBO Fellowships

Swiss National Foundation

Human Science Frontier Programme

 

Check out Gonçalo's Google Scholar and the groups LinkedIn for more information. 

Yusuf Hamied Department of Chemistry
Lensfield Road
Cambridge
CB2 1EW
T: +44 (0) 1223 336300
enquiries@ch.cam.ac.uk
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