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Currently displaying 21 - 40 of 252 publications

Merging the Isonitrile-Tetrazine (4+1) Cycloaddition and the Ugi Four-Component Reaction into a Single Multicomponent Process.

Y Méndez, AV Vasco, G Ivey, AL Dias, P Gierth, BB Sousa, CD Navo, A Torres-Mozas, T Rodrigues, G Jiménez-Osés, GJL Bernardes

Angewandte Chemie - International Edition

(2023)

e202311186

(doi: 10.1002/anie.202311186)

Merging the Isonitrile‐Tetrazine (4+1) Cycloaddition and the Ugi Four‐Component Reaction into a Single Multicomponent Process

Y Méndez, AV Vasco, G Ivey, AL Dias, P Gierth, BB Sousa, CD Navo, A Torres‐Mozas, T Rodrigues, G Jiménez‐Osés, GJL Bernardes

Angewandte Chemie

(2023)

135

(doi: 10.1002/ange.202311186)

Designed Endocytosis-Triggering Proteins mediate Targeted Degradation.

B Huang, M Abedi, G Ahn, B Coventry, I Sappington, R Wang, T Schlichthaerle, JZ Zhang, Y Wang, I Goreshnik, CW Chiu, A Chazin-Gray, S Chan, S Gerben, A Murray, S Wang, J O'Neill, R Yeh, A Misquith, A Wolf, LM Tomasovic, DI Piraner, MJD Gonzalez, NR Bennett, P Venkatesh, D Satoe, M Ahlrichs, C Dobbins, W Yang, X Wang, D Vafeados, R Mout, S Shivaei, L Cao, L Carter, L Stewart, JB Spangler, GJL Bernardes, KT Roybal, P Greisen, X Li, C Bertozzi, D Baker

bioRxiv

(2023)

2023.08.19.553321

(doi: 10.1101/2023.08.19.553321)

Multiplexed Digital Characterisation of Misfolded Protein Oligomers via Solid-State Nanopores

S Sandler, R Horne, S Rocchetti, R Novak, N-S Hsu, MC Cruz, F Brotzakis, R Gregory, S Chia, G Bernardes, U Keyser, M Vendruscolo

(2023)

(doi: 10.1101/2023.08.09.552642)

Targeted protein modification with an antibody-based system

O Rimon, J Konc, M Ali, V Roy Chowdhury, I Černauskienė, P Sormanni, G Bernardes, M Vendruscolo

(2023)

(doi: 10.1101/2023.07.28.551006)

De Novo Human Angiotensin-Converting Enzyme 2 Decoy NL-CVX1 Protects Mice From Severe Disease After Severe Acute Respiratory Syndrome Coronavirus 2 Infection.

M Rebelo, C Tang, AR Coelho, C Labão-Almeida, MM Schneider, L Tatalick, P Ruivo, MP de Miranda, A Gomes, T Carvalho, MJ Walker, H Ausserwoeger, J Pedro Simas, M Veldhoen, TPJ Knowles, D-A Silva, D Shoultz, GJL Bernardes

The Journal of Infectious Diseases

(2023)

228

723

(doi: 10.1093/infdis/jiad135)

Unlocking the Potential of Bio‐Based Nitrogen‐Rich Furanic Platforms as Biomass Synthons

RFA Gomes, BMF Gonçalves, KHS Andrade, BB Sousa, N Maulide, GJL Bernardes, CAM Afonso

Angewandte Chemie

(2023)

135

(doi: 10.1002/ange.202304449)

Unlocking the Potential of Bio‐Based Nitrogen‐Rich Furanic Platforms as Biomass Synthons

RFA Gomes, BMF Gonçalves, KHS Andrade, BB Sousa, N Maulide, GJL Bernardes, CAM Afonso

Angewandte Chemie International Edition

(2023)

e202304449

(doi: 10.1002/anie.202304449)

Expanding Transition Metal-Mediated Bioorthogonal Decaging to Include C–C Bond Cleavage Reactions

GM Dal Forno, E Latocheski, A Beatriz Machado, J Becher, L Dunsmore, AL St John, BL Oliveira, CD Navo, G Jiménez-Osés, R Fior, JB Domingos, GJL Bernardes

J Am Chem Soc

(2023)

145

10790

(doi: 10.1021/jacs.3c01960)

Proximity-Induced Nucleic Acid Degrader (PINAD) Approach to Targeted RNA Degradation Using Small Molecules.

S Mikutis, M Rebelo, E Yankova, M Gu, C Tang, AR Coelho, M Yang, ME Hazemi, M Pires de Miranda, M Eleftheriou, M Robertson, GS Vassiliou, DJ Adams, JP Simas, F Corzana, JS Schneekloth, K Tzelepis, GJL Bernardes

ACS Central Science

(2023)

892

(doi: 10.1021/acscentsci.3c00015)

Introducing the 2023 Bioconjugate Chemistry Editorial Team

GJL Bernardes, P Zou, Z Dai, E Lavik, J van Hest, G Zheng, N Quinn, CM MacLaughlin, TM Reineke

Bioconjugate chemistry

(2023)

279

(doi: 10.1021/acs.bioconjchem.3c00033)

SnapShot: Clinical and preclinical utility of click chemistry

S Mikutis, GJL Bernardes

Cell

(2023)

186

662

(doi: 10.1016/j.cell.2023.01.018)

Strategies for Conditional Regulation of Proteins

K Nadendla, GG Simpson, J Becher, T Journeaux, M Cabeza-Cabrerizo, GJL Bernardes

JACS Au

(2023)

344

(doi: 10.1021/jacsau.2c00654)

A Selective SARS-CoV-2 Host-Directed Antiviral Targeting Stress Response to Reactive Oxygen Species

C Tang, AR Coelho, M Rebelo, H Kiely-Collins, T Carvalho, GJL Bernardes

ACS Central Science

(2023)

109

(doi: 10.1021/acscentsci.2c01243)

Cysteine‐Assisted Click‐Chemistry for Proximity‐Driven, Site‐Specific Acetylation of Histones

CF Afonso, MC Marques, JPM António, C Cordeiro, PMP Gois, PMSD Cal, GJL Bernardes

Angewandte Chemie

(2022)

134

(doi: 10.1002/ange.202208543)

Fragment-based computational design of antibodies targeting structured epitopes.

M Aguilar Rangel, A Bedwell, E Costanzi, RJ Taylor, R Russo, GJL Bernardes, S Ricagno, J Frydman, M Vendruscolo, P Sormanni

Sci Adv

(2022)

eabp9540

(doi: 10.1126/sciadv.abp9540)

Selective Inhibition of Bruton’s Tyrosine Kinase by a Designed Covalent Ligand Leads to Potent Therapeutic Efficacy in Blood Cancers Relative to Clinically Used Inhibitors

BB Sousa, CR de Almeida, AF Barahona, R Lopes, A Martins-Logrado, M Cavaco, V Neves, LAR Carvalho, C Labão-Almeida, AR Coelho, M Leal Bento, RMRM Lopes, BL Oliveira, MARB Castanho, P Neumeister, A Deutsch, GI Vladimer, N Krall, C João, F Corzana, JD Seixas, R Fior, GJL Bernardes

ACS Pharmacology & Translational Science

(2022)

1156

(doi: 10.1021/acsptsci.2c00163)

Cysteine‐Assisted Click‐Chemistry for Proximity‐Driven, Site‐Specific Acetylation of Histones

CF Afonso, MC Marques, JPM António, C Cordeiro, PMP Gois, PMSD Cal, GJL Bernardes

Angew Chem Int Ed Engl

(2022)

e202208543

(doi: 10.1002/anie.202208543)

Chemical and Enzymatic Methods for Post-Translational Protein-Protein Conjugation

RJ Taylor, MB Geeson, T Journeaux, GJL Bernardes

J Am Chem Soc

(2022)

144

14404

(doi: 10.1021/jacs.2c00129)

π-Clamp-Mediated Homo- and Heterodimerisation of Single Domain Antibodies via Site-Specific Homobifunctional Conjugation

RJ Taylor, M Aguilar Rangel, MB Geeson, P Sormanni, M Vendruscolo, GJL Bernardes

Journal of the American Chemical Society

(2022)

144

13026

(doi: 10.1021/jacs.2c04747)

Interested in joining the GBernardesLab?

We are always looking for enthusiastic and bright researchers to join the lab. If you are interested in joining the group, please contact Gonçalo directly at gb453@cam.ac.uk.

All applications should include a cover letter that highlights your research interests, a full CV, and the names and addresses of two referees.

Funded PhD and Postdoctoral positions will be advertised when available through the university jobs portal.

Postdoctoral researchers are encouraged to obtain their own fellowships. Potential funding sources include:

Marie Curie Actions

Royal Society Newton International Fellowships

Fundação para a Ciência e a Tecnologia

EMBO Fellowships

Swiss National Foundation

Human Science Frontier Programme