Publications

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Currently displaying 81 - 100 of 271 publications

Dichloro Butenediamides as Irreversible Site‐Selective Protein Conjugation Reagent

V Laserna, D Abegg, CF Afonso, EM Martin, A Adibekian, P Ravn, F Corzana, GJL Bernardes

Angewandte Chemie

(2021)

133

23943

(doi: 10.1002/ange.202108791)

Dichloro Butenediamides as Irreversible Site‐Selective Protein Conjugation Reagent

V Laserna, D Abegg, CF Afonso, EM Martin, A Adibekian, P Ravn, F Corzana, GJL Bernardes

Angewandte Chemie (International ed. in English)

(2021)

23750

(doi: 10.1002/anie.202108791)

Combating small-molecule aggregation with machine learning

K Lee, A Yang, Y-C Lin, D Reker, GJL Bernardes, T Rodrigues

Cell Reports Physical Science

(2021)

100573

(doi: 10.1016/j.xcrp.2021.100573)

METTL1-mediated m⁷G modification of Arg-TCT tRNA drives oncogenic transformation

EA Orellana, Q Liu, E Yankova, M Pirouz, E De Braekeleer, W Zhang, J Lim, D Aspris, E Sendinc, DA Garyfallos, M Gu, R Ali, A Gutierrez, S Mikutis, GJL Bernardes, ES Fischer, A Bradley, GS Vassiliou, FJ Slack, K Tzelepis, RI Gregory

Molecular cell

(2021)

3323

(doi: 10.1016/j.molcel.2021.06.031)

Exploration of Long-Chain Vitamin E Metabolites for the Discovery of a Highly Potent, Orally Effective, and Metabolically Stable 5-LOX Inhibitor that Limits Inflammation.

K Neukirch, K Alsabil, C-P Dinh, R Bilancia, M Raasch, A Ville, I Cerqua, G Viault, D Bréard, S Pace, V Temml, E Brunner, PM Jordan, MC Marques, K Loeser, A Gollowitzer, S Permann, J Gerstmeier, S Lorkowski, H Stuppner, U Garscha, T Rodrigues, GJL Bernardes, D Schuster, D Séraphin, P Richomme, A Rossi, AS Mosig, F Roviezzo, O Werz, J-J Helesbeux, A Koeberle

Journal of medicinal chemistry

(2021)

11496

(doi: 10.1021/acs.jmedchem.1c00806)

Arylethynyltrifluoroborate Dienophiles for On Demand Activation of IEDDA Reactions

Z Zawada, Z Guo, BL Oliveira, CD Navo, H Li, PMSD Cal, F Corzana, G Jiménez-Osés, GJL Bernardes

Bioconjug Chem

(2021)

1812

(doi: 10.1021/acs.bioconjchem.1c00276)

Protein Conjugation by Electrophilic Alkynylation Using 5-(Alkynyl)dibenzothiophenium Triflates.

V Laserna, A Istrate, K Kafuta, TA Hakala, TPJ Knowles, M Alcarazo, GJL Bernardes

Bioconjugate chemistry

(2021)

1570

(doi: 10.1021/acs.bioconjchem.1c00317)

Allosteric Antagonist Modulation of TRPV2 by Piperlongumine Impairs Glioblastoma Progression

J Conde, RA Pumroy, C Baker, T Rodrigues, A Guerreiro, BB Sousa, MC Marques, BP de Almeida, S Lee, EP Leites, D Picard, A Samanta, SH Vaz, F Sieglitz, M Langini, M Remke, R Roque, T Weiss, M Weller, Y Liu, S Han, F Corzana, VA Morais, CC Faria, T Carvalho, P Filippakopoulos, B Snijder, NL Barbosa-Morais, VY Moiseenkova-Bell, GJL Bernardes

ACS Central Science

(2021)

868

(doi: 10.1021/acscentsci.1c00070)

The role of reversible and irreversible covalent chemistry in targeted protein degradation.

H Kiely-Collins, GE Winter, GJL Bernardes

Cell Chemical Biology

(2021)

952

(doi: 10.1016/j.chembiol.2021.03.005)

Precise protein conjugation technology for the construction of homogenous glycovaccines

A Kitowski, F Corzana, GJL Bernardes

Drug Discov Today Technol

(2021)

(doi: 10.1016/j.ddtec.2020.11.007)

Fragment-based computational design of antibodies targeting structured epitopes

MA Rangel, A Bedwell, E Costanzi, R Taylor, R Russo, GJL Bernardes, S Ricagno, J Frydman, M Vendruscolo, P Sormanni

(2021)

2021.03.02.433360

(doi: 10.1101/2021.03.02.433360)

A structural ensemble of a tau-microtubule complex reveals regulatory tau phosphorylation and acetylation mechanisms

ZF Brotzakis, P Lindstedt, R Taylor, G Bernardes, M Vendruscolo

ACS Central Science

(2021)

(doi: 10.21203/rs.3.rs-215084/v1)

TRPV2 Modulation by Small Molecules and Lipids

AD Protopopova, RA Pumroy, J de la Roche, FM Haug, BB Sousa, PN Gallo, GJL Bernardes, A Leffler, VY Moiseenkova-Bell

BIOPHYSICAL JOURNAL

(2021)

120

112A

Facile Installation of Post-translational Modifications on the Tau Protein via Chemical Mutagenesis.

PR Lindstedt, RJ Taylor, GJL Bernardes, M Vendruscolo

ACS Chem Neurosci

(2021)

557

(doi: 10.1021/acschemneuro.0c00761)

Multi-scale microporous silica microcapsules from gas-in water-in oil emulsions (vol 16, pg 3586, 2020)

Z Toprakcioglu, TA Hakala, A Levin, CFW Becker, GJL Bernardes, TPJ Knowles

Soft Matter

(2020)

201

(doi: 10.1039/d0sm90246b)

In Vivo Pretargeting Based on Cysteine-Selective Antibody Modification with IEDDA Bioorthogonal Handles for Click Chemistry.

VFC Ferreira, BL Oliveira, A D'Onofrio, CM Farinha, L Gano, A Paulo, GJL Bernardes, F Mendes

Bioconjugate chemistry

(2020)

121

(doi: 10.1021/acs.bioconjchem.0c00551)

Systematic Activity Maturation of a Single-Domain Antibody with Non-canonical Amino Acids through Chemical Mutagenesis.

PR Lindstedt, FA Aprile, P Sormanni, R Rakoto, CM Dobson, GJL Bernardes, M Vendruscolo

Cell Chemical Biology

(2020)

(doi: 10.1016/j.chembiol.2020.11.002)

Adaptive Optimization of Chemical Reactions with Minimal Experimental Information

D Reker, EA Hoyt, GJL Bernardes, T Rodrigues

Cell Reports Physical Science

(2020)

100247

(doi: 10.1016/j.xcrp.2020.100247)

A Structural Ensemble of a Tau-Microtubule Complex Reveals Regulatory Tau Phosphorylation and Acetylation Mechanisms

ZF Brotzakis, PR Lindstedt, R Taylor, GJL Bernardes, M Vendruscolo

biorxiv

(2020)

2020.11.10.376285

(doi: 10.1101/2020.11.10.376285)

Structural Characterization of an Unprecedented Lectin-like Antitumoral anti-MUC1 Antibody

J Macías-León, IA Bermejo, A Asín, A García-García, I Compañón, E Jiménez-Moreno, H Coelho, V Mangini, IS Albuquerque, F Marcelo, JL Asensio, GJL Bernardes, HJ Joshi, R Fiammengo, O Blixt, R Hurtado-Guerrero, F Corzana

Chemical communications (Cambridge, England)

(2020)

15137

(doi: 10.1039/d0cc06349e)

Interested in joining the GBernardesLab?

We are always looking for enthusiastic and bright researchers to join the lab. If you are interested in joining the group, please contact Gonçalo directly at gb453@cam.ac.uk.

All applications should include a cover letter that highlights your research interests, a full CV, and the names and addresses of two referees.

Funded PhD and Postdoctoral positions will be advertised when available through the university jobs portal.

Postdoctoral researchers are encouraged to obtain their own fellowships. Potential funding sources include:

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Human Science Frontier Programme

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