Publications

Tips on using this search form

All search terms are case-insensitive
If you specify more than one search option (e.g. you search for both "Authors" and "Paper title") then the publications returned will be those that match all of your search terms
To reset the search form, click here

Currently displaying 81 - 100 of 266 publications

METTL1-mediated m<sup>7</sup>G modification of Arg-TCT tRNA drives oncogenic transformation.

EA Orellana, Q Liu, E Yankova, M Pirouz, E De Braekeleer, W Zhang, J Lim, D Aspris, E Sendinc, DA Garyfallos, M Gu, R Ali, A Gutierrez, S Mikutis, GJL Bernardes, ES Fischer, A Bradley, GS Vassiliou, FJ Slack, K Tzelepis, RI Gregory

Mol Cell

(2021)

3323

(doi: 10.1016/j.molcel.2021.06.031)

Exploration of Long-Chain Vitamin e Metabolites for the Discovery of a Highly Potent, Orally Effective, and Metabolically Stable 5-LOX Inhibitor that Limits Inflammation

K Neukirch, K Alsabil, C-P Dinh, R Bilancia, M Raasch, A Ville, I Cerqua, G Viault, D Bréard, S Pace, V Temml, E Brunner, PM Jordan, MC Marques, K Loeser, A Gollowitzer, S Permann, J Gerstmeier, S Lorkowski, H Stuppner, U Garscha, T Rodrigues, GJL Bernardes, D Schuster, D Séraphin, P Richomme, A Rossi, AS Mosig, F Roviezzo, O Werz, J-J Helesbeux, A Koeberle

J Med Chem

(2021)

11496

(doi: 10.1021/acs.jmedchem.1c00806)

Arylethynyltrifluoroborate Dienophiles for on Demand Activation of IEDDA Reactions.

Z Zawada, Z Guo, BL Oliveira, CD Navo, H Li, PMSD Cal, F Corzana, G Jiménez-Osés, GJL Bernardes

Bioconjugate chemistry

(2021)

1812

(doi: 10.1021/acs.bioconjchem.1c00276)

Protein Conjugation by Electrophilic Alkynylation Using 5‑(Alkynyl)dibenzothiophenium Triflates

V Laserna, A Istrate, K Kafuta, TA Hakala, TPJ Knowles, M Alcarazo, GJL Bernardes

Bioconjug Chem

(2021)

1570

(doi: 10.1021/acs.bioconjchem.1c00317)

Allosteric Antagonist Modulation of TRPV2 by Piperlongumine Impairs Glioblastoma Progression

J Conde, RA Pumroy, C Baker, T Rodrigues, A Guerreiro, BB Sousa, MC Marques, BP de Almeida, S Lee, EP Leites, D Picard, A Samanta, SH Vaz, F Sieglitz, M Langini, M Remke, R Roque, T Weiss, M Weller, Y Liu, S Han, F Corzana, VA Morais, CC Faria, T Carvalho, P Filippakopoulos, B Snijder, NL Barbosa-Morais, VY Moiseenkova-Bell, GJL Bernardes

ACS Central Science

(2021)

868

(doi: 10.1021/acscentsci.1c00070)

The role of reversible and irreversible covalent chemistry in targeted protein degradation

H Kiely-Collins, GE Winter, GJL Bernardes

Cell chemical biology

(2021)

952

(doi: 10.1016/j.chembiol.2021.03.005)

Precise Protein Conjugation Technology for the Construction of Homogenous Glycovaccines

A Kitowski, F Corzana, GJL Bernardes

Drug Discovery Today: Technologies

(2021)

(doi: 10.1016/j.ddtec.2020.11.007)

Fragment-based computational design of antibodies targeting structured epitopes

MA Rangel, A Bedwell, E Costanzi, R Taylor, R Russo, GJL Bernardes, S Ricagno, J Frydman, M Vendruscolo, P Sormanni

(2021)

2021.03.02.433360

(doi: 10.1101/2021.03.02.433360)

A structural ensemble of a tau-microtubule complex reveals regulatory tau phosphorylation and acetylation mechanisms

ZF Brotzakis, P Lindstedt, R Taylor, G Bernardes, M Vendruscolo

ACS Central Science

(2021)

(doi: 10.21203/rs.3.rs-215084/v1)

TRPV2 Modulation by Small Molecules and Lipids

AD Protopopova, RA Pumroy, J de la Roche, FM Haug, BB Sousa, PN Gallo, GJL Bernardes, A Leffler, VY Moiseenkova-Bell

BIOPHYSICAL JOURNAL

(2021)

120

112A

Facile Installation of Post-translational Modifications on the Tau Protein via Chemical Mutagenesis

PR Lindstedt, RJ Taylor, GJL Bernardes, M Vendruscolo

ACS Chem Neurosci

(2021)

557

(doi: 10.1021/acschemneuro.0c00761)

In Vivo Pretargeting Based on Cysteine-Selective Antibody Modification with IEDDA Bioorthogonal Handles for Click Chemistry

VFC Ferreira, BL Oliveira, A D'Onofrio, CM Farinha, L Gano, A Paulo, GJL Bernardes, F Mendes

Bioconjugate chemistry

(2020)

121

(doi: 10.1021/acs.bioconjchem.0c00551)

Systematic Activity Maturation of a Single-Domain Antibody with Non-canonical Amino Acids through Chemical Mutagenesis

PR Lindstedt, FA Aprile, P Sormanni, R Rakoto, CM Dobson, GJL Bernardes, M Vendruscolo

Cell chemical biology

(2020)

(doi: 10.1016/j.chembiol.2020.11.002)

Adaptive Optimization of Chemical Reactions with Minimal Experimental Information

D Reker, EA Hoyt, GJL Bernardes, T Rodrigues

Cell Reports Physical Science

(2020)

100247

(doi: 10.1016/j.xcrp.2020.100247)

Structural Characterization of an Unprecedented Lectin-like Antitumoral anti-MUC1 Antibody

J Macías-León, IA Bermejo, A Asín, A García-García, I Compañón, E Jiménez-Moreno, H Coelho, V Mangini, IS Albuquerque, F Marcelo, JL Asensio, GJL Bernardes, HJ Joshi, R Fiammengo, O Blixt, R Hurtado-Guerrero, F Corzana

Chem Commun (Camb)

(2020)

15137

(doi: 10.1039/d0cc06349e)

A Structural Ensemble of a Tau-Microtubule Complex Reveals Regulatory Tau Phosphorylation and Acetylation Mechanisms

ZF Brotzakis, PR Lindstedt, R Taylor, GJL Bernardes, M Vendruscolo

biorxiv

(2020)

2020.11.10.376285

(doi: 10.1101/2020.11.10.376285)

Structure of a protective epitope reveals the importance of acetylation of Neisseria meningitidis serogroup A capsular polysaccharide

P Henriques, L Dello Iacono, A Gimeno, A Biolchi, MR Romano, A Arda, GJL Bernardes, J Jimenez-Barbero, F Berti, R Rappuoli, R Adamo

Proceedings of the National Academy of Sciences of the United States of America

(2020)

117

29795

(doi: 10.1073/pnas.2011385117)

meCLICK-Seq – a substrate-hijacking and RNA degradation strategy for the study of RNA methylation

S Mikutis, M Gu, E Sendinc, ME Hazemi, H Kiely-Collins, D Aspris, GS Vassiliou, Y Shi, K Tzelepis, GJL Bernardes

ACS central science

(2020)

2196

(doi: 10.1021/acscentsci.0c01094)

Mechanistic insights into transition metal-mediated bioorthogonal uncaging reactions

E Latocheski, GM Dal Forno, TM Ferreira, BL Oliveira, GJL Bernardes, JB Domingos

Chem Soc Rev

(2020)

7710

(doi: 10.1039/d0cs00630k)

Sequential dual site-selective protein labelling enabled by lysine modification.

MJ Matos, L Brown, B Bernardim, A Guerreiro, G Jiménez-Osés, GJL Bernardes

Bioorganic and Medicinal Chemistry

(2020)

115783

(doi: 10.1016/j.bmc.2020.115783)

Interested in joining the GBernardesLab?

We are always looking for enthusiastic and bright researchers to join the lab. If you are interested in joining the group, please contact Gonçalo directly at gb453@cam.ac.uk.

All applications should include a cover letter that highlights your research interests, a full CV, and the names and addresses of two referees.

Funded PhD and Postdoctoral positions will be advertised when available through the university jobs portal.

Postdoctoral researchers are encouraged to obtain their own fellowships. Potential funding sources include:

Marie Curie Actions

Royal Society Newton International Fellowships

EMBO Fellowships

Swiss National Foundation

Human Science Frontier Programme

Check out Gonçalo's Google Scholar and the groups LinkedIn for more information.